A General Organocatalytic System for Enantioselective Radical Conjugate Additions to Enals

Herein, we report a general iminium ion-based catalytic method for the enantioselective conjugate addition of carbon-centered radicals to aliphatic and aromatic enals. The process uses an organic photoredox catalyst, which absorbs blue light generate from stable precursors, in combination with chiral amine secures consistently high level stereoselectivity. generality this platform is demonstrated by stereoselective interception wide variety radicals, including non-stabilized primary ones are generally difficult engage asymmetric processes. system also served develop organocatalytic cascade reactions that combine iminium-ion-based radical trap enamine-mediated step, affording stereochemically dense products one-step.